Gesellschaft für Informatik e.V.

Lecture Notes in Informatics

German Conference on Bioinformatics 2005 (GCB 2005), 5.-7. October 2005, Hamburg, Germany P-71, 133-144 (2005).



Andrew Torda, Stefan Kurtz, Matthias Rarey (eds.)


Family specific rates of protein evolution

Hannes Luz and Martin Vingron


Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework. We find that the evolution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate.

Full Text: PDF

ISBN 3-88579-400-4

Last changed 24.01.2012 21:51:55