Gesellschaft für Informatik e.V.

Lecture Notes in Informatics

German conference on bioinformatics 2010 P-173, 51-60 (2010).

Gesellschaft für Informatik, Bonn

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Efficient similarity retrieval of protein binding sites based on histogram comparison

Thomas Fober , Marco Mernberger , Gerhard Klebe and Eyke Hüllermeier


We propose a method for comparing protein structures or, more specifically, protein binding sites using a histogram-based representation that captures important geometrical and physico-chemical properties. In comparison to hitherto existing approaches in structural bioinformatics, especially methods from graph theory and computational geometry, our approach is computationally much more efficient. Moreover, despite its simplicity, it appears to capture and recover functional similarities surprisingly well.

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Gesellschaft für Informatik, Bonn
ISBN 978-3-88579-267-3

Last changed 04.10.2013 18:32:34