Gesellschaft für Informatik e.V.

Lecture Notes in Informatics

German conference on bioinformatics 2009 P-157, 81-92 (2009).

Gesellschaft für Informatik, Bonn

Copyright © Gesellschaft für Informatik, Bonn


Identifying hot cancer and novel novel cell-cycle genes from literature

L. Royer , C. Plake and M. Schroeder


Gene prioritization based on background knowledge mined from literature has become an important method for the analysis of results from high-throughput experimental assays such as gene expression microarrays, RNAi screens and genomewide association studies. We apply our gene mention identifier, which achieved the best result of over 80\% in the BioCreative II text-mining challenge [HPR+08], and show how text-mined associations can be complemented using guilt-by-association on high confidence protein interaction networks. First, we predict hand-curated gene-disease relationships in the OMIM database, Entrez Gene summaries and GeneRIFs with 37\% success rate. Second, we confirm 24\% of novel cell-cycle genes identified in a recent RNAi screen [KPH+07] by using text-mining and high confidence protein interactions. Moreover, we show how 71\% of GOA cell-cycle annotations can be automatically recovered. Third, we devise a method to rank genes based on novelty, increasing interest, impact, and popularity.

Full Text: PDF

Gesellschaft für Informatik, Bonn
ISBN 978-3-88579-251-2

Last changed 04.10.2013 18:29:27