Gesellschaft für Informatik e.V.

Lecture Notes in Informatics

German Conference on Bioinformatics GCB 2007 September 26 - 28, 2007, Potsdam, Germany P-115, 185-197 (2007).

Gesellschaft für Informatik, Bonn


Claudia Falter (ed.), Alexander Schliep (ed.), Joachim Selbig (ed.), Martin Vingron (ed.), Dirk Walther (ed.)

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Revealing comprehensive genotype-phenotype associations through logic relationships

Alexey Antonov and Hans W. Mewes


A novel approach which employs principles of higher order logic analyses was developed to systematically correlate phylogenetic data with phenotype profiles by identification of phenotype specific patterns of presence of multiple proteins. For example, for most genomes expressing trait A, the presence of protein C presumes the presence of protein B, while for other genomes (not expressing the trait) the presence of protein C presumes the absence of protein B. We demonstrate that the phenotype specific patterns reflect fundamental structural changes in the genotype of microorganisms in relation to conditions provided by presence/absence of a trait. We discover many previously unidentified genotypephenotype associations on the level of fundamental biochemical processes.

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Gesellschaft für Informatik, Bonn
ISBN 978-3-88579-209-3

Last changed 04.10.2013 18:15:29