Rearrangements are genomic "earthquakes" that change the chromosomal architectures. The fundamental question in molecular evolution is whether there exist "chromosomal faults" where rearrangements are happening over and over again. In 1984 Nadeau and Taylor proposed the Random Breakage Model (RBM) of chromosome evolution that recently caused a controversy. RBM postulates that rearrangements are "random", and thus there is no rearrangement hot-spots in mammalian genomes. It became the de facto theory of chromosome evolution (due to its prophetic prediction power) but in 2003 was refuted by Pevzner and Tesler who gave a non-constructive argument against RBM using a combinatorial theorem. They further proposed the Fragile Breakage Model that postulates that mammalian genomes represent a mosaic of fragile and solid regions. However, the rebuttal of RBM caused a controversy and shortly after Pevzner-Tesler work was published, Sankoff and Trinh, 2004 gave a rebuttal of the rebuttal of RBM.