Gesellschaft für Informatik e.V.

Lecture Notes in Informatics


German Conference on Bioinformatics GCB 2007 September 26 - 28, 2007, Potsdam, Germany P-115, 90-99 (2007).

Gesellschaft für Informatik, Bonn
2007


Editors

Claudia Falter (ed.), Alexander Schliep (ed.), Joachim Selbig (ed.), Martin Vingron (ed.), Dirk Walther (ed.)


Copyright © Gesellschaft für Informatik, Bonn

Contents

Understanding of SMFS barriers by means of energy profiles

Frank Dressel , Annalisa Marsico , Anne Tuukkanen , Michael Schroeder and Dirk Labudde

Abstract


In the last years, Single Molecule Force Spectroscopy was more and more used to gain insight into the fundamental principles behind protein structure and stability. Nevertheless, the interpretation of the experimental findings is not so easy and additional computational approaches are needed to interpret them. Here, we proposed an approach based on interaction patterns between amino acids to explain the emergence of SMFS unfolding barriers in the experiment. With our approach, we can predict around 64\% of the experimentally detectable barriers.


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Gesellschaft für Informatik, Bonn
ISBN 978-3-88579-209-3


Last changed 04.10.2013 18:15:26