Gesellschaft für Informatik e.V.

Lecture Notes in Informatics


German Conference on Bioinformatics 2005 (GCB 2005), 5.-7. October 2005, Hamburg, Germany P-71, 133-144 (2005).


2005


Editors

Andrew Torda, Stefan Kurtz, Matthias Rarey (eds.)


Contents

Family specific rates of protein evolution

Hannes Luz and Martin Vingron

Abstract


Amino acid changing mutations in proteins are contstrained by purifying selection and accumulate at different rates. We estimate evolutionary rates on multiple alignments of eukaryotic protein families in a maximum likelihood framework. We find that the evolution of indispensable proteins is constrained by selection and that protein secretion is coupled to an increased evolutionary rate.


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ISBN 3-88579-400-4


Last changed 24.01.2012 21:51:55