Gesellschaft für Informatik e.V.

Lecture Notes in Informatics


German Conference on Bioinformatics 2004, GCB 2004, October 4-6, 2004, Bielefeld, Germany P-53, 43-52 (2004).

GI, Gesellschaft für Informatik, Bonn
2004


Editors

Robert Giegerich (ed.), Jens Stoye (ed.)


Copyright © GI, Gesellschaft für Informatik, Bonn

Contents

Feature based representation and detection of transcription factor binding sites

R. Pudimat , Ernst-Günter Schukat-Talamazzini and Rolf Backofen

Abstract


The prediction of transcription factor binding sites is an important problem, since it reveals information about the transcriptional regulation of genes. A commonly used representation of these sites are position specific weight matrices which show weak predictive power. We introduce a feature-based modelling approach, which is able to deal with various kind of biological properties of binding sites and models them via Bayesian belief networks. The presented results imply higher model accuracy in contrast to the PSSM approach.


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GI, Gesellschaft für Informatik, Bonn
ISBN 3-88579-382-2


Last changed 04.10.2013 18:03:54